血清FGF-23在维持性血液透析患者心血管疾病发生中的作用

摘要

Objective:To explore the role of serum FGF‐23 in the presence of cardiovascular diseases (CVD) in main‐tenance hemodialysis (M HD) patients .And further to investigate the association between FGF‐23 and the presence of CVD in M HD patients .Methods:58 cases of the M HD patients and clinical data were collected in our study .According to the occurrence of CVD ,the patients were divided into CVD group and non‐CVD group .Plasma FGF‐23 concentra‐tions were determined by ELISA .Results:FGF‐23 correlated positively with dialysis age (r= 0 .37 ,P< 0 .001) and iPTH (r=0 .21 ,P=0 .048) .Patients with CVD were older (P=0 .035) ,had lower FGF‐23 (P=0 .008) ,lower Hb (P=0 .008) ,and albumin (P=0 .003) .Logistic regression analysis showed that only plasma FGF‐23 level was an in‐dependent determinant of the occurrence of CVD in MHD patients(P=0 .02) .Conclusion:Low FGF‐23 was identified as a risk factor for CVD .FGF‐23 could play a role in cardiovascular protection that remains to be confirmed in larger studies .%目的：探讨血清成纤维细胞生长因子23（FGF‐23）在维持性血液透析（M HD）患者心血管疾病（CVD）发生中的作用，进一步探讨血清FGF‐23与M HD患者CVD发生的相关性。方法：收集58例M HD患者的临床资料，根据有无CVD发生分为CVD组和非CVD组，采用ELISA法测定血清FGF‐23水平。结果：FGF‐23与透析龄（r＝0．37，P＜0.001）和iPTH（r＝0．21，P＝0．048）成正相关。CVD组年龄明显高于非CVD组（P＝0．035），CVD组血清 FGF‐23水平明显低于非CVD 组（P＝0．008），Hb明显低于非 CVD 组（P＝0．008），血清 Alb明显低于非 CVD组（P＝0.003）。Logistic回归分析结果显示，只有FGF‐23是M HD患者CVD发生的独立危险因素（P＝0．02）。结论：低水平FGF‐23可能是M HD患者CVD发生的危险因素。FGF‐23可能在心血管保护方面发挥作用，还有待更大规模样本的研究证实。