Objective:To investigate the unilateral pedicle screw fixation with single Cage implantation clinical curative effect of the treatment of degenerative disease of lumbar spine bone fusion .Methods:From March 2007 to March 2011 hospitalized in department of orthopedics in our hospital treatment of 48 cases of lesions caused by degenerative lumbar disease were randomly divided into 2 groups ,respectively using unilateral pedicle screw fixation with single Cage inter‐body fusion in the treatment of 22 cases of the treatment group is unilateral ,bilateral pedicle screw fixation and inter‐body fusion in the treatment of single Cage 26 cases were bilateral treatment group .Comparative analysis of 2 groups of patients before and after operation of Japanese Orthopedic Association (JOA ) score and visual analogue scale (VAS) ,improvement rate ,operation time ,amount of bleeding ,hospitalization days ,cost of hospitalization and postop‐erative follow‐up of Cage bone graft fusion .Results:48 patients were followed up ,followed up for 12~24 months ,aver‐age 18 months ,two groups of patients with JOA score of VAS and compares their differences had no statistical signifi‐cance (P>0 .05)before operation ,no statistical significance at the end of the follow‐up JOA score of VAS and compares their differences (P>0 .05) ,but the patients in the 2 groups compared with the preoperative JOA score of VAS and the comparison was statistically significant (P<0 .01) .The operation time ,hemorrhage volume ,length of hospitalization , cost of hospitalization ,unilateral treatment group was significantly better than the bilateral treatment group (P<0.01) .Conclusion:Unilateral pedicle screw fixation and bone grafting with single cage spine surgery is effective opera‐tion technology ,and achieve the same clinical efficacy of bilateral pedicle screw fixation of the same in the treatment of lumbar degenerative disease .And this technique has short operation time ,intraoperative blood loss ,less failure ,low treatment cost and other advantages of small on the spine has a wide clinical application of space .%目的：探讨单侧椎弓根钉固定加单枚Cage植骨融合治疗腰椎退行性疾病的临床疗效。方法：将2007年3月－2011年3月在我院骨科住院治疗的48例由退行性病变引起腰椎疾病的患者随机分成两组，采用单侧椎弓根钉固定加单枚Cage植骨融合治疗的22例为单侧治疗组，采用双侧椎弓根钉固定加单枚Cage植骨融合治疗的26例为双侧治疗组。对比分析两组患者手术前、后日本矫形外科协会评分（JOA）及疼痛视觉模拟评分（VAS）、改善率、手术时间、出血量、住院天数、住院费用及术后随访Cage植骨融合情况。结果：48例患者均获得随访，随访时间12～24个月，平均18个月，术前两组患者JOA及VAS评分比较差异无统计学意义（P＞0．05），末次随访JOA及VAS评分比较差异无统计学意义（P＞0．05），但两组患者较术前JOA及VAS评分比较均有统计学意义（P＜0．01）。在手术时间、出血量、住院天数、住院费用方面，单侧治疗组明显优于双侧治疗组（P＜0．01）。结论：单侧椎弓根钉固定加单枚Cage植骨融合术是行之有效的脊柱外科手术，同时在治疗腰椎退行性疾病方面能取得同双侧椎弓根钉内固定相同的临床疗效。并且本术式具有手术时间短、术中失血量少、对脊柱破坏小、治疗费用低廉等优点，具有广阔临床应用空间。
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