Objective To study the measurement and the association of early arteriosclerosis with HbAlc in newly diagnosed type 2 diabetes mellitus. Methods Totally 125 newly diagnosed type 2 diabetetes (T2DM) were divided into HbAlc <8.5% group, HbAlc 8. 5% - 10. 0% group and HbAlc > 10% group. 41 health persons were as normal control group. Fasting plasma glucose, plasma glucose of the 120 min after 75g oral glucose tolerance, total cholersterol, triglyceride, low - density lipoprotein cholesterol ( LDL - C) , high -density lipoprotein cholesterol ( HLDL - C) , HbAlc, carotid - femoral pulse wave velocity ( cf - PWV) , cardio - ankle vascular index (CAVI) and ankle - brachial index ( ABI) were measured and evaluated in all newly diabetes mellitus and normal control subjects. The relationship between cf-PWV, CAVI and ABI and HbAlc were analyzed. Results Total cholersterol, triglyceride, LDL -C, fasting plasma glucose, two hours plasma glucose, HbAlc, cf-PWV and CAVI were significantly higher (P<0.05 or P<0.01) and HDL - C and ABI were lower ( P < 0. 05 ) in newly diagnosed diabetes mellitus than normal control subjects ( P < 0. 05 or P < 0. 01 ). And they were increased with the increasing of HbAl c. There was significant difference among the three different HbAl c groups also ( P < 0. 05 or P < 0.01). The correlation analysis showed that c - f PWV and CAVI were positively correlated with HbAl c (R = 0. 612 ,P < 0.01 and R = 0.537,P<0.01) and ABI was negatively correlated with HbAlc (R= -0. 442,P < 0. 05). Conclusion The cf-PWV, CAVI and ABI were abnormal in newly diagnosed diabetes mellitus and significantly correlated with HbAlc.%目的 通过对初诊2型糖尿病早期动脉硬化指标进行检测,并探讨其与血糖水平和糖化血红蛋白的相关性.方法 125例初诊2型糖尿病患者,根据HbA1c水平分为HbA1c ＜8.5％组、HbA1c 8.5％～10.0％组和HbA1c＞ 10％组,另选41例健康人作为正常对照组.所有受试者均测定空腹血糖,糖负荷后2h血糖、总胆固醇、三酰甘油、LDL-C、HLDL-C及HbA1c.同时测定颈股脉搏波速度(cf-PWV)、心踝血管指数(CAVI)、和踝臂指数(ABI).比较不同HbA1c分组之间及其与正常对照组间上述指标的而变化,分析cf-PWV、CAVI和ABI与HbA1c的关系.结果 不同HbA1c分组中总胆固醇、三酰甘油、LDL-C、空腹血糖、餐后2h血糖、HbA1c、cf-PWV和CVAI均显著高于正常对照组(P＜0.05或P＜0.01),且随HbA1c升高呈升高趋势,HDL-C和ABI显著低于正常对照组(P＜0.05),随HbA1c升高呈降低趋势.上述指标在不同HbA1c分组中具有统计学差异(P＜0.05或P＜0.01).对初诊2型糖尿病患者的单因素相关分析显示,cf-PWV和CVA与HbA1c具有显著正相关(R=0.612,P＜0.01和R=0.537,P＜0.01),ABI与HbA1c具有显著负相关(R=-0.442,P＜0.05).结论 初诊2型糖尿病cf-PWV、CVAI 和ABI等动脉硬化指标出现异常,与HbA1c水平显著相关.
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