经静脉尿激酶溶栓在治疗门静脉高压症脾切除术后门静脉血栓的疗效观察

摘要

Objective To evaluate the effect of intravenous urokinase thrombolysis in the treatment of portal vein thrombosis( PVT) after splenectomy.Methods Sixty three PVT patients were included into the retrospective study and devided into two groups according to anticoagulation therapy or thrombolytic therapy.The general condition and effect of treatment were compared.Results There was no sig-nificant difference in the general situation of two groups of patients (P>0.05).The efficiency of thrombolytic treatment group was signifi-cantly higher than anticoagulation group (P<0.01).Conclusion Intravenous urokinase thrombolysis in the treatment of portal vein thrombosis( PVT) after splenectomy is effectiye and safe.%目的：评价经静脉尿激酶溶栓在治疗门静脉高压症脾切除术后门静脉血栓（ PVT）的效果。方法回顾性研究63例脾切除贲门周围血管离断术后发生PVT患者，分别给予抗凝、祛聚治疗及溶栓治疗，比较两组患者的一般情况及PVT治疗效果。结果两组患者的一般情况比较，差异无统计学意义（P＞0．05），PVT治疗效果，溶栓组治疗有效率显著高于抗凝、祛聚组（ P＜0.01）。结论对于脾切除术后预防性应用抗凝、祛聚治疗仍发生PVT的患者，经静脉应用尿激酶溶栓治疗作为一种补救性治疗手段，可取得较好效果，且方法相对简便，可行性强，较少发生严重并发症。