YKL-40在炎症性疾病中的作用及其信号通路研究进展

摘要

YKL-40, a newly found inflammatory marker, is belonged to the mammals′chitinase family.It showed that YKL-40 can participate in a variety of inflammatory diseases such as airway inflammatory diseases, cardiovascular and neurological inflamma-tory diseases, and arthritis etc.It could be used to diagnose and evaluate these inflammatory diseases.Since its specific receptor has not been identified, the exact biological role of YKL-40 in inflammatory response still remains unclear.This article reviews the function of YKL-40 in inflammatory response and its related signaling pathways.%YKL-40是近年来新发现的一种炎性标记物，属于哺乳动物壳质酶家族。研究表明YKL-40在气道、心血管、神经、关节等相关炎症性疾病中发挥了重要作用，可作为炎性疾病预防和治疗的新切入点，辅助炎性疾病的诊断、病情判断和预后评估。然而，YKL-40的特异性细胞膜受体仍未发现，其在炎症反应中所涉及的信号通路还有待进一步明确和完善。文中就近年来YKL-40在炎性疾病中的作用及相关信号通路的最新研究进展进行综述。