Objective: Study on the clinical value of SPECT, evaluating whether transient ischemia attack (TIA) progressed to cerebral infarction. Methods : We conducted brain SPECT and MRI in 97 transient ischemia attack of internal carotid artery system within 72 hours. Patients were semi-quantitative analyzed from the total counts obtained from each region of interest the asymmetry index (AI) was calculated as follows : 〔( value in unaffected region-value in afected region)/value in unaffected region〕 ×lOO. The patients were divided into 3 groups according to the grade of AI. Clinic assessment of patients were performed at the 6 monhs of the onset of TIA. Analyzing the relationship among brain hypoperfusion,progressing to cerebral infarction, frequency. duration of attacks and history of stroke. Results : 97 TIA patients divided into 3 groups by asymmetry index ( Al). The 3 groups were different in progressing to cerebral infarction, frequency, duration of attacks and history of stroke. 35 patients progressing to cerebral infarction were different from the others in Al,frequency, duration of attacks and history of stroke. Conclusion: SPECT can be used to assess the cerebral blood flow and predict prognosis. The decrement of brain hypoperfusion increase risk of stroke, which should be positive treatment.%目的:探讨SPECT脑血流灌注显像评估短暂性脑缺血发作(TIA)进展为脑梗死的临床应用价值.方法:对97例颈内动脉系统TIA患者发病72h内进行SPECT脑血流灌注显像及磁共振检查.对感兴趣区放射性计数进行半定量分析,按如下公式计算脑血流的不对称指数(AI):[(正常区域放射性计数-感兴趣区放射性计数)/正常区域放射性计数]×100.人组患者根据不对称指数分为轻度(AI≤5)、中度(5＜AI≤10＝、重度(AI＞10)组.发病6个月后对各组患者进行临床评估,分析低灌注程度与是否进展为脑梗死、发作持续时间、发作次数及卒中史之间的关系.结果:97例TIA患者,根据低灌注程度分为轻、中、重三组,三组间在是否进展为脑梗死、发作次数、发作持续时间、卒中史具有显著的统计学差异.进展为脑梗死患者在低灌注程度、发作次数、发作持续时间、卒中史上与未进展为脑梗死患者比较,差异有统计学意义.结论:SPECT脑血流灌注显像检查能观察TIA患者脑血流情况,可评估TIA预后.对于低灌注程度严重的患者,进展为脑梗死风险更大,应积极防治.
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