Objective To investigate the severities of the atrial electrophysiological abnormalities in patients with hyper ‐trophic obstructive cardiomyopathy (HOCM ) compared with healthy controls and to evaluate the effects of percutaneous transluminal septal myocardial ablation (PTSMA) on the atrial electrophysiological conduction parameters .Methods We selectd 25 HOCM patients before and 6 months after septal ablation procedures and 26 healthy controls ,all of whom re‐ceived conventional echocardiography and tissue Doppler imaging .The intervals from the initiation of the P wave on the e‐lectrocardiogram (ECG) to the onsets of TDI‐derived late diastolic velocity at the lateral mitral annulus (P‐LA) ,anterior mitral annulus (P‐IVS) and tricuspid annulus (P‐RA) were measured .The intratrial asynchrony was defined as the differ‐ence between P‐LA and P‐IVS(T1 ) ,while ,the interatrial asynchrony as the difference between P‐LA and P‐RA(T2 ) .Re‐sults Compared with healthy controls ,P‐LA ,P‐IVS ,P‐RA and T1 ,T2 were significantly prolonged in HOCM patients . Moreover ,at 6 months after PTSMA ,the P‐LA ,P‐IVS ,P‐RA and T1 ,T2 were significantly decreased in HOCM pa‐tients .Conclusion Left atrial electromechanical conduction time ,left intratrial and interatrial asynchrony were significant‐ly prolonged in HOCM patients .PTSMA can improve the prolonged conduction time and asynchrony for HOCM patients .%目的：探讨肥厚型梗阻性心肌病（HOCM ）患者心房电‐机械传导异常的严重程度及经皮室间隔化学消融术（PTSMA）对患者电‐机械传导异常改善的有效性。方法选择成功进行 PTSMA 术并术后6个月进行随访的 HOCM 组25例和正常对照组26例。测量心动图 P 波起始点至心尖四腔观二尖瓣环左室侧壁、后间隔及三尖瓣环右室侧壁位点处组织多普勒曲线上 a 波起始点的时间（P‐LA 、P‐IVS 、P‐RA），计算左心房内不同步性（P‐LA 与 P‐IVS 差值 T1）、左右心房间不同步性（P‐LA 与 P‐RA 的差值 T2）。结果与正常对照组相比，HOCM 患者手术前、后 P‐LA 、P‐IVS 、P‐RA 均明显延长（ P ＜0．05），T1、T2值明显增大（ P ＜0．05）；与 HOCM 患者术前相比，术后 P‐LA 、P‐IVS 、P‐RA 均显著缩短（ P ＜0．05），T1、T2值明显减小（ P ＜0．05）。结论 HOCM 患者存在心房电‐机械传导间期延长、左心房内及左右心房间不同步运动，而 PTSMA 术使患者这种心房电‐机械活动异常及心房不同步运动得到显著改善。
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