正常人和结直肠癌患者血清的拉曼光谱探测与区别

摘要

Herein, Raman spectra of serum trom normal people and colorectal cancer patients were compared and analyzed. The information of Raman peaks and that of the fluorescence background were selected as parameters for statistical analysis. Principal component regression (PCR) combinded with linear discriminant analysis (LDA) were used on the selected parameters to see the performance of the parameters, we got a diagnostic accuracy of 87. 50%. The conclusion is that the selected parameters can maintain the information of original spectra well and Raman spectroscopy of serum has the potential for the diagnosis of colorectal cancer.%本文对比分析了正常人和结直肠癌患者的血清的拉曼光谱.选择拉曼峰信息和荧光背景信息作为参数进行统计分析.用主成分回归(Principal component regression,PCR)和线性辨别分析(linear discriminant analysis,LDA)对所选参数进行分析以观察这些参数对光谱的代表性,得到了87.50%的准确率.得到的结论为,本实验所选参数能较好保留原始光谱信息,血清的拉曼光谱具有诊断结直肠癌的潜力.