Objective To study the efficacy of azithromycin combined with simvastatin in the treatment of chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension.Methods From January 2014 to July 2016,79 patients with COPD complicated with pulmonary hypertension treated in our hospital were selected,and divided into two groups by random number table.In the control group,39 cases were given azithromycin,while in the observation group,40 cases were given azithromycin combined with simvastatin.The clinical curative effect and adverse drug reactions between the two groups were compared.Results Before treatment,forced vital capacity (FVC),forced expiratory volume in 1 second (FEV1),total cholestrol (TC),triacylglycerol (TG) of the two groups were compared,with no statistically significant differences (P>0.05).After treatment,FVC,FEV1,TC,TG of observation group were significantly better than those before treatment,and FVC,FEV1,TC,TG of observation group were significantly lower than those of the control group (P<0.05).There was no significant difference in the rate of adverse drug reactions between the two groups (P>0.05).Conclusion Azithromycin combined with simvastatin in the treatment of COPD complicated with pulmonary hypertension is effective,which is safe and reliable and worthy to be spread in clinical application.%目的 探讨阿奇霉素与辛伐他汀联合治疗慢性阻塞性肺疾病(COPD)合并肺动脉高压的疗效.方法 取2014年1月至2016年7月期间我院收治的COPD合并肺动脉高压患者79例,采用随机数字表法将患者分为两组,对照组39例,采用阿奇霉素治疗,观察组40例在对照组基础上采用辛伐他汀治疗,比较两组临床疗效与药物不良反应.结果 治疗前,两组患者用力肺活量(FVC)、一秒用力呼吸容积(FEV1)、血清总胆固醇(TC)与三酰甘油(TG)水平比较差异无统计学意义(P>0.05),治疗后,观察组患者FVC、FEV1、TC、TG水平明显优于治疗前,且观察组FVC、FEV1、TC、TG水平明显低于对照组(P<0.05).两组患者药物不良反应率比较差异无统计学意义(P>0.05).结论 阿奇霉素与辛伐他汀联合治疗COPD合并肺动脉高压的疗效满意,安全可靠,值得临床推广应用.
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