EB病毒与淋巴瘤转化的研究进展

摘要

Epstein-Barr virus (EBV) is one of the most common human herpesviruses, presenting a latent infection in more than 95% of healthy adults. EBV can regulate the differentiation, proliferation and colony formation of infected lymphocytes by coding viral proteins, and it is associated with Burkitt lymphoma, NK/T cell lymphoma, Hodgkin lymphoma, and vascular immunoblastic lymphoma. This article reviews the research progress of EBV in lymphoma transformation.%EB病毒(EBV)是最常见的人类疱疹病毒之一,在超过95%的健康成年人中以潜伏感染形式存在. EBV可以通过编码的病毒蛋白调控受感染淋巴细胞的分化、增殖以及克隆形成,与伯基特淋巴瘤、自然杀伤(NK)／T细胞淋巴瘤、霍奇金淋巴瘤以及血管免疫母细胞淋巴瘤等发生相关.文章就EBV在淋巴瘤转化过程中的研究进展进行综述.