血管内皮细胞生长因子在非霍奇金淋巴瘤中的表达及其临床意义

摘要

目的 观察血管内皮细胞生长因子(VEGF)在非霍奇金淋巴瘤(NHL)中的表达水平与疾病的恶性程度、近期疗效和预后的关系.方法 免疫组织化学法检测39例NHL淋巴结石蜡包埋标本VEGF的表达水平,9例良性淋巴结病变标本作为对照.结果 NHL组VEGF表达阳性率为79.5%,明显高于对照组的44.4%(P=0.048).在NHL组中,侵袭性组VEGF的表达高于惰性组(x2=5.284,P=0.044);随着分期的升高,VEGF的表达也升高;VEGF高表达者,血清乳酸脱氢酶(LDH)升高,化疗缓解率低,临床预后差,3年生存率低.结论 VEGF在NHL组织中的表达升高,且与患者的临床分期、病理恶性程度相关,也能预示化疗的效果与预后.%Objective To detect the expression of VEGF in NHL and analyze the relation of the expression levels with malignant aggressiveness,treatment response,and prognosis.Methods The expression of VEGF in lymph nodes taken from 39 NHL patients Wag measured by immunohistochemical-staining method.9 patients with benign lymphadenopathy were acted as control.Results The expression of VEGF in NHL(79.5%)was higher than that in the contrel(44.4%)(P=0.048＜0.05).In NHL,the VEGF level was higher in aggressive lympboma than that in indolent lymphoma(x2=5.284,P=0.044＜0.05).The patients had the higher-level expression as the Ann Arbor stage Wag higher,and the patients who had the higher-level expression of VEGF had higher serum LDH level,lower chemotherapy remission,unfavorable prognosis and lower 3-year survival (P＜0.05).Conclusion The expression of VEGF in NHL was increased.It was correlated with histopathological grade,Ann Arbor stage,chemotherapy response and prognosis.