多发性骨髓瘤分子细胞遗传学异常及发病机制:第55届美国血液学会年会报道

摘要

The effect of molecular cytogenetics in pathogenesis of multiple myeloma (MM) is fundamental.The risk stratification system that based on molecular cytogenetics of MM is widely applicable in the prognosis of MM.The aberration of molecular cytogenetics is the most important marker of MM.At the same time,high-risk MM is associated with intra-clonal tumor heterogeneity and clonal evolution.The research of intra-clonal tumor heterogeneity and clonal evolution which based on the aberration of molecular cytogenetics will provide some additional information of the biology of MM and contribute to the optimum treatment for MM patients.%分子细胞遗传学异常在多发性骨髓瘤(MM)发病中发挥着重要作用,基于分子细胞遗传学异常的危险因素分层已经被大家所接受并逐渐应用于临床,它已经成为MM最重要的分子标志.并且分子细胞遗传学异常与克隆异质性和克隆进化关系密切,高危细胞遗传学异常患者更容易出现克隆异质性和克隆进化现象.以分子细胞遗传学异常为基础的克隆进化和克隆异质性研究可为进一步认识MM生物学特性及实施个体化治疗奠定基础.