目的研究地佐辛（dezocine，DZ）对神经病理性疼痛大鼠的镇痛作用，并探讨其可能机制．方法脊神经结扎（SNL）模型雄性SD大鼠24只，随机分为3组：第1组（生理盐水组，n＝8），SNL手术后14 d腹腔内注射生理盐水1 mL；第2组（地佐辛组，n＝8），SNL手术后14 d腹腔内注射地佐辛5 mg/kg，总容量1 mL；第3组（吗啡组，n＝8），SNL手术后14 d腹腔内注射吗啡5 mg/kg，总容量1 mL．结果腹腔内注射地佐辛及吗啡对神经病理性疼痛大鼠有明显镇痛作用，持续时间为4～6 h．连续注射吗啡3 d后产生明显的耐受作用，而地佐辛连续注射7 d后仍有明显的镇痛作用．结论腹腔内注射地佐辛及吗啡能明显抑制SNL大鼠神经病理性疼痛，连续注射吗啡3d后产生明显耐受，地佐辛则在连续注射7d后仍有镇痛作用．%Objective To study wether dezocine (DZ) can attenuate neuropathic pain in rats and to investigate its mechanism.Methods Neuropathic pain was induced by tight ligation of the left L5 spinal nerve of the male SD rats. 24 Spinal nerve ligation (SNL) model rats were randomly divided into three groups:the first group (saline group, n=8), rats were given intraperitoneal injection of 1ml of saline 14 days after SNL surgery; the second group (dezocine group, n=8), rats were given intraperitoneal injection of 5mg/kg of dezocine in 1ml saline 14 days after SNL surgery;the third group (morphine group,n=8),rats were given intraperitoneal injection of 5 mg/kg of morphine 14 days after SNL surgery. Results Intraperitoneal injection dezocine and morphine had significant analgesic effect in neuropathic pain rats. This analgesic effect lasted for 4-6 hours.Continuous injection of morphine for 3 days produced significant tolerance, while continuous injection of dezocine for 7 days still had significant analgesic effect on neuropathic pain. Conclusion Intraperitoneal injection of dezocine and morphine can attenuate SNL neuropathic pain, continuous injection of morphine for 3 days can produce significant tolerance, while continuous injection of dezocine for 7 days still has significant analgesic effect on neuropathic pain.
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