云南地区人乳头瘤病毒16型感染及与其他亚型混合感染状况分析

摘要

Objective To investigate the distribution of Human Papillomavirus 16 (HPV16) infection and its mixed infection with other HPV subtypes in the Yunnan region. Methods 16 166 cases of women were tested using flow fluorescence Luminex technology. Results (1) HPV16 infection rate and mixed infection rate was 2.2%and 28.0%, respectively; (2) The most common type of HPV16 mixed infection was HPV52, followed by HPV33. The two kinds of mixed infection accounted for 39.8% of the total infection rate; (3) There was a significant difference between each age group of HPV16 mixed infection (Chi=26.39, <0.01) . Conclusion The HPV16 infection was mainly HPV infection in Yunnan region. HPV16 mixed infection merged mainly with HPV52 and HPV33. HPV16 mixed infection was associated with age.%目的：云南地区乳头瘤病毒（human papillo maviruses，HPV）16型感染及与其他亚型混合感染状况．方法运用流式荧光Luminex技术对16166例女性进行26种 HPV分型检测，统计HPV16型感染率及HPV16型与其他亚型混合感染在云南地区的分布状况．结果（1） HPV16型感染率为2.2%，HPV16型混合感染率为28.0%；（2） HPV16型混合感染以HPV52型最为常见，其次为HPV33型，此2种混合感染占总感染率的39.8%；（3） HPV16型混合感染在各年龄组的感染率，随着年龄增加比率降低（＜0.05）．结论云南地区HPV16型为HPV感染主要型别，HPV16型混合感染以合并HPV52和HPV33型常见．HPV16型混合感染与年龄有一定关系．