硫酸镁联合布地奈德、硫酸特布他林雾化吸入治疗毛细支气管炎疗效

摘要

目的 观察硫酸镁联合布地奈德、硫酸特布他林雾化吸入治疗毛细支气管炎的临床疗效.方法 将60例毛细支气管炎患儿随机分为观察组与对照组,每组各30例,给予对照组患儿常规综合治疗,观察组在对照组基础上加用硫酸镁联合布地奈德、硫酸特布他林雾化吸入治疗.分别从临床症状、血清炎性因子以及总体临床疗效几方面对治疗效果进行评价.结果 观察组患儿的气喘、气促、咳嗽、肺部哮鸣音及湿口音消失时间均显著短于对照组患儿(P＜0.05);经过治疗,2组患儿的TNF-α、IL-6、IL-8、TIgE血清水平均显著降低,与治疗前比较差异有统计学意义(P＜0.05),但治疗后组间比较以观察组患儿的改善效果更为明显,与对照组比较差异有统计学意义(P＜0.05);观察组患儿的临床总有效率为93.3％,对照组为70.0％,组间比较差异有统计学意义(P＜0.001).结论 硫酸镁联合布地奈德、硫酸特布他林雾化吸入治疗毛细支气管炎的临床疗效满意,值得在临床推广应用.%Objective To observe the clinical efficacy of magnesium sulfate inhalation combined with budesonide and terbutaline sulfate nebulizer for the treatment of bronchiolitis.Methods Sixty children with bronchiolitis were randomly divided into observation group and control group with 30 cases in each group.Children in the control group received routine treatment and the observation group were inhaled with magnesium sulfate combining budesonide and terbutaline sulfate.Curative effects were evaluated in the aspects of the clinical symptoms,serum inflammatory factors and overall clinical efficacy.Results The symptoms in children including asthma,shortness of breath,coughing,wheezing and lung auscultation were significantly alleviated within a shorter period of time than that in the control group (P＜0.05).The serum levels of TNF-u,IL-6,IL-8 and TIgE were significantly reduced in both groups after the treatment (P＜0.05).But in the observation group,the alleviation of the symptoms was significantly greater than that in the control group (P＜0.05).The overall effective rate in the observation group and the control group was 93.3％ and 70.0％ respectively (P＜0.001).Conclusion The clinical efficacy of inhaling magnesium sulfate with budesonide and terbutaline sulfate to treat bronchiolitis is satisfactory and worth clinical application.