ADAM33基因T1、S2位点多态性在中国人支气管哮喘易感性的Meta分析

摘要

Objective To investigate the correlation between ADAM33 T1, S2 gene polymorphism and Bronchial asthma risk in china. Methods We retrived the relevant published studies about ADAM33 T1, S2 gene polymorphism and bronchial asthma risk. Then we divided the population into Chinese and other Asian population. Odds ratio (OR) of Case group and control group was selected as the effect index. Stata 11.0 software was used to calculate heterogeneity test, ORs and 95%CI of two areas, and gave the forest plot and funnel plot of meta results. Results A total of 27 studies were included in this analysis,18 studies in ADAM33 T1 site were 3881 cases in case group, and 3780 cases in control group;and 14 studies in ADAM33 S2 site were 3222 cases in case group, and 3513 cases in control group. Additive model, dominant model, recessive model of ADAM33 T1 in Chinese had association with the susceptibility of bronchial asthma. The results were OR=1.488, 95% CI:1.002-2.167 in Additive model, OR=1.619, 95%CI:1.059-2.475 in dominant model;OR=2.523, 95%CI:1.910-3.333 in recessive model. Three models of ADAM33 T1 in other Asian country had no association with the susceptibility of Bronchial Asthma. Three gene model of ADAM33 S2 in Asian had no association with bronchial asthma susceptibility. Except ADAM33 T1 polymorphism in recessive model, other mode of T1, S2 had no publication bias in Chinese population. Conclusion There are association between ADAM33 T1 gene polymorphism and bronchial asthma, but ADAM33 S2 gene polymorphism and bronchial asthma have no association in Chinese population.%目的：探讨中国人ADAM33基因T1、S2位点多态性与支气管哮喘易感性的相关性．方法检索发表关于ADAM33基因T1、S2位点多态性与支气管哮喘易感性的研究，把研究对象分为亚洲其他地区和中国人，以病例组与对照组比值比（odds ratio, OR）为效应指标，应用Stata版软件分别计算两地区人合并OR值及95%CI，异质性检验，发表偏倚，同时给出Meta分析森林图和倒漏斗图．结果共纳入27篇文献，其中ADAM33基因T1位点18篇，病例组3881例，对照组3780例，S2位点14篇，病例组3222例，对照组3513例，ADAM33 T1位点在中国人加性、显性、隐形基因模式与支气管哮喘易感性具有相关性．加性模式下OR值为1.488（95%CI：1.002～2.167）；显性模式下OR值为1.619（95%CI：1.059～2.475）；隐形模式下OR值为2.523（95%CI：1.910～3.333）；ADAM33 T1位点在亚洲其他国家人群加性、显性、隐形基因模式与支气管哮喘易感性不具有相关性，ADAM33 S2位点在亚洲国家加性、显性、隐形基因模式与支气管哮喘易感性不具有相关性．除见ADAM33 T1位点隐形模式下中国人具有发表偏倚，其他T1位点模式，S2位点均未见发表偏倚．结论中国人ADAM33基因T1位点多态性与支气管哮喘易感性有相关性，而S2位点多态性与哮喘未见相关性．