PPARδ调控巨噬细胞的功能与动脉粥样硬化关系

摘要

过氧化物酶体增殖物激活受体δ(PPARδ)含有6个结构域,是过氧化物酶体增殖物激活受体的亚型之一.PPARδ通过配体依赖、配体非依赖的转录抑制及配体依赖的转录激活等方式发挥病理生理作用,参与动脉粥样硬化等多种疾病的病理过程.研究显示,巨噬细胞对动脉粥样硬化所有病变阶段均具有重要的影响,PPARδ可通过调控巨噬细胞的多种功能介导动脉粥样硬化的病理过程.PPARδ通过调控巨噬细胞胞葬作用、脂质代谢、浸润、炎症及极化状态,发挥抗动脉粥样硬化的作用.PPARδ可能是一个有效的防治动脉粥样硬化的靶点,但是PPARδ在调控巨噬细胞相关功能研究方面还存在不足之处,仍需进一步探索.%Peroxisome proliferator-activated receptor delta(PPARδ) containing 6 domains is one of the subtypes of peroxisome proliferator-activated receptor.PPARδ plays a pathophysiological role through ligand-dependent, or ligand-independent transcriptional inhibitions and ligand-dependent transcriptional activation, which are involved in the pathological process of various diseases including atherosclerosis.Studies have shown that macrophages have an important effect on all stages of atherosclerosis, and PPARδ can mediate the pathological process of atherosclerosis by regulating the functions of macrophages.PPARδ plays an anti-atherosclerosis role through regulating efferocytosis, lipid metabolism, recruitment, inflammation and polarization of macrophages.PPARδ could be an effective target for the prevention and treatment of atherosclerosis,but there are also shortcomings in the study of macrophage-related functions regulated by PPARδ,which remains to be further explored.