布-加综合征介入治疗近期效果评价中脾脏剪切波速与门静脉压力相关性研究

摘要

Objective To discuss the application of the correlation between spleen shear wave velocity (SWV) and portal vein pressure in evaluating short-term curative effect of interventional therapy for Budd-Chiari syndrome (BCS).Methods The clinical data of a total of 30 BCS patients,who were admitted to authors' hospital during the period from May 2016 to October 2016 to receive treatment,were collected.The hepatic venous pressure gradient (HVPG) was measured before as well as after percutaneous transluminal angioplasty in all patients.Spleen SWV,the velocity and internal diameter as well as the velocity-to-diameter ratio of portal vein were calculated,the results were statistically analyzed.Results Technical success was achieved in all 30 patients.The mean HVPG score was strikingly reduced from preoperative (13.70±4.55)mmHg to postoperative (3.20±1.94) mmHg (P＜0.05).The preoperative and postoperative difference in HVPG had a parallel relationship with the preoperative and 2-day postoperative difference in spleen SWV as well as with the preoperative and 2-day postoperative difference in velocity-to-diameter ratio (r=0.856,P＜0.0001 and r=0.741,P＜0.0001 respectively).Conclusion A significant correlation exists between the spleen SWV and HVPG,therefore,SWV can be used as an effective index to evaluate the short-term curative effect of interventional treatment for BCS.%目的 探讨脾脏剪切波速(SWV)与门静脉压力相关性在布-加综合征(BCS)介入治疗近期效果评价中的应用价值.方法 收集2016年5月至10月收治的30例BCS患者临床资料,检测受治血管开通前后2次肝静脉压力梯度(HVPG),检测介入术前、术后2d及术后1个月脾脏SWV、门静脉流速及内径并计算其比值,并对上述指标进行统计学分析.结果 30例患者均治疗成功.HVPG均值由术前(13.70±4.55) mmHg显著下降至术后(3.20±1.94) mmHg(P＜0.05);术前、术后HVPG差值与术前、术后2d脾脏SWV差值及门静脉流速-内径差值均呈正相关(r=0.856,P＜0.000 1;r=0.741,P＜0.000 1).结论 脾脏SWV与HVPG有良好相关性,可用于评价BCS患者术后近期疗效.