天然抗氧化剂在人精液冷冻保存中的应用

摘要

精液的冷冻保存是辅助生殖技术的基础，但精液冻融过程会产生过多的活性氧自由基（ROS），破坏精子的生理结构，使其质量下降，造成受精能力下降。目前，有些研究开始关注抗氧化剂在精液冷冻保存过程中的保护作用。其中一些来源于植物的天然抗氧化剂（如白藜芦醇、槲皮苷、染料木黄酮等），这些物质的来源广泛，抗氧化能力非常高，而且毒性较低，可以有效抑制精子冻融后ROS的产生，减少精子在冷冻过程中受到的氧化损伤，从而保护精子的活力和遗传稳定性，可以作为冷冻保护剂的添加成份用于改良精子的冷冻保存。%Sperm cryopreservation technique is a basis of assisted reproduction. However,the additional reactive oxygen species (ROS) was produced in the freezing-thawing process,which damaged the physiological structure and function of spermatozoa,and lowered sperm quality and fertility. At present,there were some studies on the protective roles of antioxidants in the sperm cryopreservation. Some natural antioxidants derived from plants are widespread,high efficient and low toxicity. These natural antioxidants can significantly inhibit ROS production,eliminate the sperm damage caused by ROS,and protect sperm activity and genetic stability. In future,these natural antioxidants may be used as additional ingredients in cryoprotective agent for improving sperm cryopreservation.