NR4A1, one of orphan nuclear receptors, is involved in cell survival and apoptosis. Studies about subcellular localization showed that NR4A1 was mainly localized in nucleus as a nuclear transcript factor. Besides, NR4A1 was also found in cytoplasm, especially in mitochondria, which mediated cell function via the mitochondria-related mechanisms. In nucleus, NR4A1 acted as a nuclear factor promoting cell proliferation, while in cytoplasm, NR4A1 promoted apoptosis and autophagy directly or indirectly through mitochondria-related signaling pathways. Researches about NR4A1 involving in cell apoptosis and autophagy were reviewed in this study.%孤核受体NR4A1参与调节细胞生存和凋亡.亚细胞定位研究发现,NR4A1定位于细胞核,表明其核因子的功能;在细胞质中也存在NR4A1,主要定位在线粒体,提示其通过线粒体机制调节细胞凋亡和自噬功能.在细胞核内,NR4A1作为一种促进细胞增殖的核因子发挥功能;在细胞质中,NR4A1与Bcl-2家族基因相互作用,通过直接或间接影响线粒体功能,导致细胞色素C释放入胞质,经线粒体相关的信号机制促进细胞凋亡,或在细胞自噬过程中发挥作用.现综述NR4A1通过线粒体参与细胞内的凋亡和自噬过程,探讨NR4A1在细胞质中的功能.
展开▼
