How to compounds that regulate apoptosis and producing and screening compounds that regulate apoptosis and methods

摘要

As a variant or fragment BAD with amino acid substitutions of serine -155 (57) forms of [summary] new, is provided with a polynucleotide that encodes the. For activity in promoting the preparation method of the variant BAD polypeptides, the cell survival or apoptosis, a method for screening drug candidate compounds or, for phosphatase activity capable of dephosphorylating BAD, a method of candidate compounds and screening for agents, for kinase activity with the ability to phosphorylate BAD, the activity of promoting phosphorylation way candidate compounds and screening for agents, BAD, anti -BAD antibodies, methods of candidate compounds and screening drugs, and inhibiting and apoptosis how to induce are also described.