Oral modified-release multiple-unit dosa ge forms such as coated pellets have always been more effective therapeutic alternative to conventional single-unit dosage forms. Coated pellets ranging in size,typically,between 0.5-1.0 mm,are produced primarily for the purpose of oral controlled-release dosage forms having gastro-resistant or sustained-release properties or the capability of site-specific drug delivery. With regards to the final dosage form,the multi-particulates are usually formulated into single-unit dosage forms such as filling them into hard gelatin capsules or compressing them into tablets. As drug-delivery systems become more sophisticated,the role of pellets in the design and development of dosage forms is increasing. The safety and efficacy of the formulation is higher than that of other dosage forms. This review provides an update on this research area and discusses the phenomena and mechanisms of the multi-particulate system concluding multiple-unit pellet system and pellet-containing tablets.%膜控微丸作为一种新型的剂量分散型调释制剂，具有比常规制剂更佳的治疗效果。它的粒径大多分布在0.5～1.0 mm，终剂型为胶囊剂或微丸压片剂，可实现药物的恒定释放、定时脉冲释放或肠道定位释药等。膜控微丸的安全性和有效性优势显著。随着新型释药系统研究和应用的不断深入，膜控微丸在新产品研发中的角色正被广泛关注，已成为缓控释制剂的主要发展方向。本文综述了膜控微丸的典型特性和应用，及其在行业发展中的巨大潜力，并分析其在产业化过程中的优势与不足。
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