循证医学在早产防治中的应用

摘要

Preterm birth is one of obstetric complications and is the primarycause of perinatal mortality and morbidity. Therefore, prediction and early diagnosis of preterm labor, become one of obstetric research focus in recent years. Domestic and international obstetric community and neonatology have done a lot of researches on many aspects including the physical indicators, laboratory biochemical, immunological indicators, the use of tocolyfic drugs, antibiotic applications, and promotion of fetal lung maturation. They have brought a lot of approaches of prevention, treatment of preterm labor and reduction of perinatal mortality and morbidity. It focuses on introducing measurement of cervical length with transvaginal ultrasound, cervical cerclage, progesterone preparation( 17-α-hydroxyprogesterone caproate), cytokine (C-reactive protein) and medicine supplementarytherapy (vitamin C and vitamin E) from evidence-based medicine in prevention and therapy of preterm birth.%早产是产科常见并发症之一,是围生儿死亡和发病的首要病因.因此早产的预测和早期诊断是当前产科研究热点之一.国内外产科和新生儿科研究者做了大量研究,从物理指标、实验室生化指标、免疫指标、使用宫缩抑制剂及保胎药物、抗生素的应用、促胎肺成熟等方面提出许多预防、治疗早产和降低围生儿死亡、发病的方法.从循证医学的角度介绍阴道超声测量宫颈长度、宫颈环扎术、孕激素及其制剂(17-α己酸羟孕酮)、细胞因子(C反应蛋白)、药物(维生素C和维生素E)补充疗法等在早产防治中的作用.