妇科肿瘤与炎症

摘要

证据表明,炎症在恶性肿瘤的发生、发展等方面发挥着重要作用,同时固有免疫的某些信号分子,如选择素、趋化因子及其受体能促进肿瘤细胞侵袭、迁移和转移,从而促进肿瘤转移.肿瘤细胞、周围正常的宿主基质细胞和浸润的炎性细胞共同组成一个整体--肿瘤微环境,这一微环境包含各类炎性细胞和炎性分子,是肿瘤细胞持续增殖的基础.研究炎症与妇科肿瘤的关系有助于了解妇科肿瘤发病机制,为妇科肿瘤治疗提供新策略.%There are growing evidences showing that inflammation plays an important role in carcinogenesis,development and metastasis and other aspects. In addition, some signaling molecules involved in innate immunity such as selectins, chemokines and their receptors can promote tumor cell invasion, migration and metastasis. Tumor cells, the surrounding normal host stromal cells and infiltrating inflammatory cells, together constitute tumor microenvironment, the micro-environment that contains various types of inflammatoy cells and molecules is the basis for the continued proliferation of tumor cells, Research on the relationship between inflammation and gynecologic malignanies will not only help to understand the pathogenesis of gynecologic malignancies, but also provide a new strategy for the treatment of gynecologic malignancies.