多囊卵巢综合征与甲状腺功能减退关系的研究进展

摘要

多囊卵巢综合征(PCOS)是一种发病多因性、病理生理和临床表现多样的内分泌综合征.研究显示,PCOS患者的甲状腺疾病发病率增高.早期的学者主要是对神经内分泌和免疫方面进行研究,认为PCOS可影响垂体-甲状腺功能轴,并使患者免疫系统受到过度刺激.近期新的研究在分子生物学水平上取得突破,认为PCOS患者的促性腺激素释放激素受体基因变异与甲状腺功能有关.同时,甲状腺功能的改变也可能影响PCOS患者排卵功能及胰岛素敏感性等.%Polycystic ovarian syndrome (PCOS) is a heterogeneous and polymorphic endocrine disease. Studies have shown that patients with PCOS had a higher incidence of thyroid disease. Earlier studies mainly consider that women with PCOS can affect the pituitary-thyroid axis,and their immune system was over-stimulated . Recently,new research reveals that genetic variation in the 3'-untranslated region of gonadotropin-releasing hormone receptor is associated with thyroid function in PCOS patients. At the same time,changes in thyroid function can affect ovulation disorders and insulin resistance in women with PCOS.