肿瘤细胞减灭术应用于复发性卵巢癌治疗进展

摘要

The treatment of recurrent ovarian cancer is the difficulty in gynecologic oncology. Its treatments include surgery,chemotherapy,targeted therapy,biological therapy,etc. The cytoreductive surgery is a treatment of recurrent ovarian cancer,including secondary cytoreductive surgery and multiple cytoreductive surgery. Principle treatment of recurrent ovarian cancer is ensuring patients′quality of life and prolonging the survival time as long as possible. Strict surgical indications were involved in secondary cytoreductive surgery and multiple cytoreductive surgery. It is a key role that all visible leision must be removed during the cytoreductive surgery in recurrent ovarian cancer as much as possible ,in order to minimize the tumor burden and reduce the clones of resistant-drug. Secondary or multiple cytoreductive surgery is more complex ,multidisciplinary collaboration is required to complete the surgery and take good care after surgery. With premise of unchanging the quality of survival patients recovery should be promoted under multidisciplinary collaboration. Chemotherapy after optimal secondary or multiple cytoreductive surgery may improve the overall survival of patients.The rule of treatment must be complied.%复发性卵巢癌是妇科肿瘤治疗的难点，治疗方法包括手术、化疗、靶向治疗、生物治疗等多个方面。肿瘤细胞减灭术是复发性卵巢癌的治疗方法之一，包括再次肿瘤细胞减灭术和多次肿瘤细胞减灭术。复发性卵巢癌的治疗原则是保证患者生存质量的同时最大限度地延长其生存时间。因此对于复发性卵巢癌的再次肿瘤细胞减灭术必须有严格的手术指征，最大限度地切除所有肉眼可见病灶，最大限度降低肿瘤负荷，降低耐药克隆数目。再次或多次肿瘤细胞减灭术手术复杂，需要多学科协作来完成手术，术后仍需要多学科协作，在不降低生存质量的前提下促进患者康复。只有达到满意效果的再次或多次肿瘤细胞减灭术，再通过术后化疗，才能改善患者的生存，这是再次或多次肿瘤细胞减灭术的治疗原则。