肥胖孕妇外周血及脐血肥胖抑制素与母儿体质指标的相关性

摘要

Objective:To investigate the association between the Obestatin levels in maternal periphery or cord blood and maternal or neonatal body index. Methods:30 obese pregnant women in Obstetrics and Gynecology Department of Affiliated Hospital of Logistical College of Chinese People′s Armed Police Force from August 2013 to September 2014 were chose as the obese group and other 35 normal weight pregnant women were chose as the contro1 group. The venous blood sample was collected in later pregnancy and cord blood sample in parturient period was gathered. ELISA was used to detect serum Obestatin level in maternal periphery and cord blood. Meanwhile, body mass index (BMI) in pregnant women was recorded, and new birth weight was recorded after birth. The LANGE skinfold caliper was used to measure the neonatal subscapular skinfold thickness, thigh skinfold thickness, suprailiac skinfold thickness, triceps skinfold thickness and hypodermic fat thickness of abdomen within 24 hours after birth. Results:Compared with control group, the obestatin levels of maternal periphery or cord blood in the obese group were statistically significant decreased (t=16.707,P=0.000). There was a negative relationship between obestatin level in maternal periphery and BMI in obese pregnant women (r=-0.898,P=0.000), and there was a negative relationship between Obestatin level in cord blood and antepartum weight and hypodermic fat thickness of abdomen (r=-0.789,P=0.000;r=-0.840,P=0.018). Conclusions:There is relation between maternal periphery Obestatin level and body index, and there is relation between cord blood Obestatin level and antepartum body index in obese pregnant women.%目的：探讨肥胖孕妇外周血与脐血肥胖抑制素（Obestatin）浓度与母儿体质指标的关系。方法：选取中国人民武装警察部队后勤学院附属医院2013年8月—2014年9月分娩的肥胖孕妇30例作为肥胖组，取同期正常体质量孕妇35例作为对照组，于孕晚期抽取外周血，于分娩时抽取脐静脉血，采用酶联免疫吸附（ELISA）法测定Obestatin浓度。同时记录母亲体质量，记录新生儿出生体质量，LANGE皮脂厚度测量仪测定新生儿肩胛下、大腿、髂上、肱三头肌及腹壁皮褶厚度。结果：对照组外周血Obestatin水平比肥胖组高，差异有统计学意义（t＝16.707，P＝0.000）；肥胖组孕妇外周血Obestatin浓度与BMI呈负相关（r=－0.898，P＝0.000）。肥胖组新生儿脐血Obestatin浓度与体质量、腹壁皮褶厚度呈负相关（r=－0.789，P＝0.000；r=－0.840，P＝0.018）。结论：肥胖孕妇外周血Obestatin浓度与母体产前BMI有关；脐血Obestatin浓度与新生儿体质指标有关。