卵巢癌是致死率最高的女性生殖系统恶性肿瘤，至今其复发转移机制不明，预后未获改善。构建理想的临床前模型有助于开展肿瘤复发转移相关机制的研究。人源性异体移植模型的出现，提供了一种高保真性的研究用临床前模型，目前已初步应用于乳腺癌、肺癌、结肠癌等相关研究，取得了良好实验结果。在卵巢癌方面，该模型的研究刚刚起步。通过对已有文献的检索发现，该模型可以较好地复制原发肿瘤的生物学特点，保留原发肿瘤的异质性。但是，在应用中仍存在一定问题亟需解决，如成瘤率不一致、组织来源有限以及缺乏有效的质量控制标准等问题。现就其研究及应用现状作一综述。%Ovarian cancer has the highest motality among the female reproductive malignancies. The underling mechanism is still unknown, and the prognosis has not been improved significantly. To establish an ideal preclinical model is in favor of the study of recurrence and metastasis in ovarian cancer. Recently, the development of patient derived xenografts model gives us a new platform for preclinical study. Gradually it has been used in the study of breast cancer, lung cancer and colon cancer, where it is proved to be useful. Much less studies on the use of patient derived xenografts model in ovarian cancer has been reported and data was shown promising. Based on the existing literature retrieval, this model could better copy the biological characteristics of the primary tumor and keep the heterogeneity of primary tumor. But there were still some problems need to be solved in the application of it, such as the different tumor take rate, the limited tumor resources and the lack of effective quality control standards. Here this review aims to address the application status, existing problems and application prospects of this model.
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