Non human animal, descendant lineage cell, tissue, organ explantation or culture of the same, use of the model of inflammatory diseases and methods for screening compounds with anti-inflammatory and evaluation

摘要

Non human animal, descendant lineage cell, tissue, organ explantation or culture of the same, use of the model of inflammatory diseases and methods for screening compounds with anti-inflammatory and evaluation. The present invention relates to a non-human animal with deficiu00ean The CLA in the field n - terminal in the gene IL - 33.Is also provided in this invention, the use of this animal model in vivo human inflammatory diseases, in particular with respect to methods of screening compounds, anti inflammatories, and methods to evaluate and optimize the pharmacological properties of a certain For the anti-inflammatory compound.