High-Throughput Screening of Compounds for Anti-Transmissible Spongiform Encephalopathy Activity Using Cell-Culture and Cell-Free Models and Infected Animals.

摘要

Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal, transmissible and untreatable neurodegenerative diseases of humans and animals. To aid in the search for anti-TSE therapeutics, we have: (1) developed new relatively high throug ...