DISEASED MODEL ANIMAL, CELL, TISSUE, ORCHIS, ANIMAL FOR MATING, METHOD FOR PRODUCING GERM CELL, GERM CELL, CULTURED CELL, SCREENING METHOD, MEDICINAL COMPOSITION, PREGNACY-DIAGNOSING KIT, DETECTION METHOD, POLYNUCLEOTIDE, POLYPEPTIDE, AND ANTIBODY

摘要

PROBLEM TO BE SOLVED: To provide a tool useful on the researches of low pregnant or sterile conditions and therapeutic methods.;SOLUTION: A Meichroacidin (MCA) homo defective mouse in which the first exon of MCA gene is deleted by a gene targeting technique exhibits azoospermia wherein sperm cells can be seen in the testis, but can not be seen in epididymis. Thus, the MCA homo defective mouse is useful as a model animal for the azoospermia.;COPYRIGHT: (C)2009,JPO&INPIT