葡萄糖酸钙联合卡前列素氨丁三醇对子痫前期产妇剖宫产后出血的临床疗效研究

摘要

目的:探讨葡萄糖酸钙联合卡前列素氨丁三醇对子痫前期产妇剖宫产后出血的临床疗效.方法:选取2016年9月-2017年9月我院产科收治的160例子痫前期以剖宫产终止妊娠的产妇为研究对象,按照随机数字表法分为研究组和对照组,各80例.在胎儿娩出后,对照组给予缩宫素和卡前列素氨丁三醇,研究组在对照组的基础上加用葡萄糖酸钙.比较2组产妇手术过程中、手术结束后2h和手术结束后24 h的出血量、产后出血率、剖宫产前后血清Ca2+浓度和血红蛋白含量,以及用药后不良反应发生率.结果:2组产妇手术过程中的出血量比较差异无统计学意义(P＞0.05);手术结束后2h和24 h,研究组的出血量均少于对照组,差异有统计学意义(均P＜0.05).研究组产后出血率为15.00％(12/80),对照组产后出血率为36.25％(29/80),差异有统计学意义(x2=9.477,P=0.002).剖宫产后,2组产妇血清Ca“浓度均比剖宫产前升高(均P＜0.05),血红蛋白含量均比剖宫产前降低(均P＜0.05).用药后不良反应发生率研究组(16.25％)和对照组(13.75％)比较差异无统计学意义(x2=0.196,P=0.658).结论:葡萄糖酸钙联合卡前列素氨丁三醇用于预防子痫前期产妇剖宫产的产后出血具有更好的止血效果且安全,值得临床推广.%Objective:To investigate the clinical effect of calcium gluconate combined with carboprost tromethamine on postpartum hemorrhage in preeclampsia cesarean section.Methods:160 pregnant women with preeclampsia who were terminated by cesarean section from September 2016 to September 2017 in our hospital were enrolled in this study,who were divided into study group and control group according to the random number table,each 80 cases.All pregnant women were terminated by cesarean section.After the fetus was delivered,the control group was given oxytocin and carboprost tromethamine,and the study group was given calcium gluconate on the basis of the control group.The amount of bleeding during the operation,2 h and 24 h after surgery and the postpartum hemorrhage rate were compared between the two groups.The serum concentrations of Ca2+ and hemoglobin before and after cesarean section were compared between the two groups.The incidence of adverse reactions was compared between the two groups.Results:There was no significant difference in bleeding volume between study group and control group during operation (P＞0.05).The amount of bleeding in the study group was less than that in the control group at 2 h and 24 h after the operation (P＜0.05).The postpartum hemorrhage rate in the study group was 15.00％ (12/80),and the postpartum hemorrhage rate in the control group was 36.25％ (29/80),which was statistically different (x2=9.477,P=0.002).After cesarean section,serum concentrations of Ca2+ increased in both groups,the study group was more significant than the control group (P＜0.05),hemoglobin content decreased in both groups,the control group decreased more than the study group (P＜0.05).There was no significant difference in the incidence of adverse reactions between the study group (16.25％) and the control group (13.75％) (x2=0.196,P=0.658).Conclusions:Calcium gluconate combined with carboprost tromethamine for preventing postpartum hemorrhage in pregnant women with preeclampsia has a better hemostatic effect,which is safe and effective and worthy of clinical promotion.