北风菌中的甾体和甾体苷类化合物

摘要

从口蘑科真菌北风菌(Pleurotus ostreatus (Jacq.:Fr.) Kummer)的乙酸乙酯部分分离鉴定了12个甾体类化合物,其中包括8个麦角甾醇类甾体及4个甾体苷.利用现代波谱技术及化学方法,鉴定了一个新化合物3-O-β-D-glucopyranosyl-22E, 24R-ergosta-7, 22-diene-5α, 6β, 9α-triol.其余11个已知化合物分别为22E, 24R-ergosta-7, 22-diene-3β, 5α, 6β, 9α-tetraol、 3-O-β-D-glucopyranosyl-22E, 24R-ergosta-7, 22-diene-5α, 6β-diol、 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6β-triol、 22E, 24R-ergosta-5, 7, 22-trien-3β-ol 3-O-β-D-glucopyranoside、 ergosterol、 22E, 24R-ergosta-7, 22-dien-3β-ol 3-O-β-D-glucopyranoside、 22E, 24R-ergosta-7, 22-diene-3β-ol、 22E, 24R-ergosta-4, 6, 8, 22-tetraen-3-one、 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6α-triol、 ergosterol peroxide 和22E, 24R-ergosta-7, 22-diene-3β, 5α-diol-6-one.%Twelve steroids, including eight ergostane-type sterols and four mono-glucosides of ergostane-type sterols, were isolated from the ethyl acetate soluble fraction of the fungus Pleurotus ostreatus (Jacq.:Fr.) Kummer. A new compound 3-O-β-D-glucopyranosyl-22E, 24R-ergosta-7, 22-diene-5α, 6β, 9α-triol, was structurally elucidated by spectroscopic and chemical methods. The eleven known compounds were 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6β, 9α-tetraol; 3-O-β-D-glucopyranosyl-22E, 24R-ergosta-7, 22-diene-5α, 6β-diol; 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6β-triol; 22E, 24R-ergosta-5, 7, 22-trien-3β-ol 3-O-β-D-glucopyranoside; ergosterol; 22E, 24R-ergosta-7, 22-dien-3β-ol 3-O-β-D-glucopyranoside; 22E, 24R-ergosta-7, 22-diene-3β-ol; 22E, 24R-ergosta-4, 6, 8, 22-tetraen-3-one; 22E, 24R-ergosta-7, 22-diene-3β, 5α, 6α-triol; ergosterol peroxide; 22E, 24R-ergosta-7, 22-diene-3β, 5α-diol-6-one.