基于纳米银-石墨烯复合材料的增强效应电化学测定对乙酰氨基酚

摘要

In this work,an Ag nanoparticles-graphene composite nanomaterial(AgNPs-GN) was prepared by redox reaction.And an Ag nanoparticles-graphene modified glass carbon electrode (Ag-NPs-GN/GCE) was fabricated by immobilizing AgNPs-GN on the surface of the glass carbon electrode.The electrochemical behaviors of paracetamol on AgNPs-GN/GCE and GN/GCE were investigated in B-R buffer solution(pH 4.78) by cyclic voltammetry and square wave voltammetry.Both modified electrodes had electrocatalytic activity for the redox of paracetamol,and the AgNPs-GN/GCE possessed a more excellent electrocatalytic effect.Under the optimal conditions,the reduction peak current of paracetamol was proportional to its concentration in the range of 1.0 × 10-7-5.0 ×10-4 mol/L with the detection limit of 3.0 × 10-8 mol/L.A new method for the determination of paracetamol in tablets was established.The modified electrode showed an excellent stability and a good reproducibility.%利用氧化还原反应制备纳米银-石墨烯复合纳米材料(AgNPs-GN),将其修饰在玻碳电极表面制备了纳米银-石墨烯修饰玻碳电极(AgNPs-GN/GCE).在pH 4.78的Britton-Robinson(B-R)缓冲溶液中,用循环伏安法(CV)和方波伏安法(Swv)研究了对乙酰氨基酚在AgNPs-GN/GCE和GN/GCE上的电化学行为.结果表明,二者对对乙酰氨基酚的氧化还原反应均有电催化作用,而且复合纳米材料AgNPs-GN具有较单一GN更好的催化效果.用方波伏安法测得对乙酰氨基酚的还原峰电流与其浓度在1.0×10-7～5.0×10-4 mol/L范围内呈线性关系,检出限(S/N=3)为3.0 × 10-8mol/L.建立了片剂中对乙酰氨基酚含量测定的新方法,修饰电极具有较好的重现性和稳定性.