Objective:To measure circulatory parameters by color Doppler imaging( CDI) in retro-bulbar vascular in early stage of diabetic retinopathy ( DR ) and to compare the results with those in healthy control subjects. Methods:CDI was used to assess circulatory parameters of ophthalmic artery ( OA ) , short posterior ciliary arteries ( PCA ) , central retinal artery ( CRA ) and central retinal vein ( CRV) in type 2 diabetes mellitus ( DM ) patients and age and sex matched healthy controls ( HC group) . We performed statistical analysis of the parameters including peak systolic velocity( PSV) ,end diastolic velocity(EDV),average velocity(MV),resistance index(RI)and pulsatility index(PI). The statistical significance level was set at P<0 . 05 . Results:Total of 75 type 2 diabetes mellitus ( DM ) patients and 20 HC group was recruited in this study. DM patients were subdivided into NDR group of 49 patients without DR and NPDR group of 26 patients with mild and moderate DR. Compared with HC group,there was a statistically significant decrease in EDV(9. 00±1. 79 VS. 6. 48±2. 35 cm/s)and MV (16. 56±3. 71 VS. 13. 93±4. 07 cm/s)in OA in NPDR group. Also RI(0. 79±0. 06 VS. 0. 72±0. 05 cm/s)and PI(1.80±0.41 VS. 1.52±0.39 cm/s)were significantly increased in NPDR group. There were significantly increased in PI in PCA in NDR group (1. 16 ±0. 31 VS. 0. 96 ±0. 19 cm/s) and NPDR group(1. 18±0. 38 VS. 0. 96±0. 19 cm/s)compared with HC group. A significantly increased in RI and PI values in CRA in NDR group(0. 63±0. 08 VS. 0. 60±0. 06 cm/s and 1. 15±0. 29 VS. 0. 95± 0. 17 cm/s)and NPDR group(0. 64±0. 08 VS. 0. 60±0. 06 cm/s and 1. 19±0. 32 VS. 0. 95±0. 17 cm/s) compared with HC group were found. And there was significantly increased in V min value in CRV in NPDR group(3.97±0.98 VS. 3.17±0.64 cm/s)compared with HC group. Conclusions:The study found significant changes of blood flow parameters in retro-bulbar vascular in the patients with type 2 DM compared with healthy control subjects,especially with early stage of DR. These results indicated that dysfunction of ocular circulation existed in DM patients with minimal or no retinopathy and it could be determined by color Doppler imaging.%目的：：应用彩色多普勒成像技术对比观察早期糖尿病视网膜病变( DR)病人和健康对照组球后血管血流动力学的差异。方法：我们采用彩色多普勒成像技术,分别测量病人的眼动脉( OA),睫状后短动脉( PCA),视网膜中央动脉(CRA)和静脉(CRV)的收缩期峰值流速(PSV),舒张末期流速(EDV)和平均流速(MV),然后计算每个血管的阻力指数( RI)和搏动指数( PI)。测量比较无糖尿病视网膜病变( NDR)组,非增殖糖尿病视网膜病变(NPDR)组和年龄、性别匹配的健康对照组(HC)组的测量结果,进行分析统计,统计显著性定为P<0.05。结果：在本研究中,观察了75位2型糖尿病病人(包括NDR 组49人,NPDR 组26人)和20位HC组。与HC组比较,NPDR组OA的EDV(9.00±1.79 VS.6.48±2.35 cm/s)和MV(16.56±3.71 VS.13.93±4.07 cm/s)显著降低(P<0.05),RI值(0.79±0.06 VS.0.72±0.05 cm/s)和PI值(1.80±0.41 VS.1.52±0.39 cm/s)显著增加(P<0.05)；NDR组(1.16±0.31 VS.0.96±0.19 cm/s)和NPDR组(1.18±0.38 VS.0.96±0.19 cm/s)的PCA 的PI值均显著增加(P<0.05)；NDR组CRA的RI和PI值分别为(0.63±0.08 VS.0.60±0.06 cm/s 和1.15±0.29 VS.0.95±0.17)和NPDR组分别为(0.64±0.08 VS.0.60±0.06 cm/s和1.19±0.32 VS.0.95±0.17 cm/s),均显著增加(P<0.05)；NPDR组的CRV的V min值显著增加(3.97±0.98 VS.3.17±0.64 cm/s)(P<0.05)。结论：本研究发现,与健康对照组相比,2型糖尿病病人球后血流参数发生显著的变化,特别是早期DR病人。这些结果表明,眼部血管循环功能异常存在于早期或者前期DR病人中,这些变化可以通过彩色多普勒成像测定。
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