骨桥蛋白与CD44 v6在乳头状甲状腺癌中的表达及意义

摘要

Objective:We detected the expression of OPN and CD44 v6 in papillary thyroid carcinoma to explore their role in the occurrence and development of papillary thyroid carcinoma. Methods:We detected the expression of OPN and CD44 v6 protein in 60 cases of papillary thyroid carcinoma by immunohistochemistry. Results:(1)The expression of OPN and CD44 v6in the papillary thyroid carcinoma were obviously stronger than in the adjacent tissues(P<0. 05). (2)The expression of OPN and CD44 v6in the papillary thyroid carcinoma weren’t associated with the patient’s sex,age. (P>0 . 05 ) . The expression of CD44 v6 in the papillary thyroid carcinoma were associated with the micro-calcifications,lymph node metastasis and cTNM stage(P<0. 05). (3)The expression of OPN and CD44 v6 had close correlation in papillary thyroid carcinoma ( P<0 . 01 , r=0 . 559 ) . Conclusions:( 1 ) The OPN and CD44 v6play a important role in the occurrence of the papillary thyroid carcinoma. (2) The expression of OPN and CD44 v6 had relation with malignancy and local infiltration of the papillary thyroid carcinoma. (3) The expression of OPN and CD44 v6had close correlation,and this indicated that OPN and CD44 v6 together play important role during the occurrence and the progression of papillary thyroid carcinoma.%目的：：研究骨桥蛋白( osteopontin,OPN)与CD44 v6在乳头状甲状腺癌中的表达情况,探讨其与乳头状甲状腺癌发生、发展的关系。方法：采用免疫组化(S-P法)检测癌组织和相癌旁结节性甲状腺肿组织中骨桥蛋白与CD44 v6的表达。结果：(1)OPN与CD44 v6在乳头状甲状腺癌组织中的表达明显高于癌旁结节性甲状腺肿组织,差异具有显著性统计学意义(P<0.05)；(2)OPN和CD44 v6的表达与病人性别、年龄无关,差异无统计学意义(P>0.05),OPN和CD44 v6的表达与微钙化、淋巴结转移、临床TNM分期相关,差异具有显著性统计学意义(P<0.05)；(3)OPN和CD44 v6在乳头状甲状腺癌中的表达存在正相关(P<0.01,r=0.559)。结论：(1) OPN和CD44 v6可能参与乳头状甲状腺癌的发生；(2)OPN和CD44 v6与乳头状甲状腺癌的恶性程度及局部浸润有关；(3)乳头状甲状腺癌组织中OPN和CD44 v6的表达存在显著相关性,表明OPN和CD44 v6共同参与了乳头状甲状腺癌的发生、发展。