牙源性角化囊性瘤开窗减压前后骨桥蛋白及 CD44 v6的表达及意义

摘要

Objective:To investigate the expression of osteopontin (OPN) and CD44v6 and their significance in keratocystic odonto-genic tumor ( KCOT) before and after decompression .Methods:All 16 pairs of paraffin-embedded tissue specimens of KCOT before and after decompression were collected and then used for immunohistochemical detection of OPN and CD 44v6.The results were statistically analyzed.Results:The expression of OPN in KCOT was down-regulated after decompression (P<0.05).And CD44v6 expression in post-operative KCOT epithelium was significantly less than that in preoperative KCOT epithelium (P<0.05).Conclusions:The local aggres-sive behavior of KCOT epithelium after decompression was decreased , which may be part of the mechanisms of decompression therapy .%目的：观察骨桥蛋白（osteopontin，OPN）及细胞粘附分子CD44v6在牙源性角化囊性瘤（keratocystic odontogenic tumor ， KCOT）中开窗减压前后表达水平的变化。方法：收集16例经病理证实的KCOT患者开窗减压前后的病理标本，应用免疫组织化学染色法检测OPN及CD44v6的表达，并进行统计分析。结果：开窗减压前，OPN及CD44v6在KCOT中均呈高表达。减压后，16例患者OPN均呈阴性表达，统计学分析其表达在开窗后显著下降（P＜0．05）；CD44v6在开窗减压后标本中，10例（63％）表达下降，5例（31％）表达未发生变化，1例（6％）表达升高，统计学分析其表达在开窗后显著下降（P＜0．05）。结论：OPN及CD44v6在KCOT中呈高表达，开窗减压后二者的表达水平明显降低，这可能是开窗减压术治疗KCOT的部分机制。