参麦注射液联合动脉灌注化疗对老年晚期非小细胞肺癌患者生活质量的影响

摘要

Objective To observe the effects of Shenmai Injection combined with Arterial Infusion Chemotherapy on life qualityof patients with no small-cell lung cancer in advanced stage. Methods From November 2010 to October 2011,80 elderly patients with no small-cell lung cancer were randomly divided into 2 groups. 40 patients in the trial group were assigned to receive Shenmai Injection combined with Arterial Infusion Chemotherapy ; 40 patients in the control group to receive Arterial Infusion Chemotherapy alone.After treatment for 2 cycles, the efficacy in the two groups was evaluated. Results There were significant differences between the two groups in the overall response rate (62.5%in the trial group vs.40.0%in control group) and disease control rate(87.5%in the trial group vs.67.5%in control group)(P<0.05 for all),And the Karnofsky performance status(KPS) improve rate of the two groups was 57.5% and 32.5% respectively,showing significant differences (P<0.05).The trial group had significantly better improvement in the side effects of Chemotherapy than the control group(P<0.05). Conclusion Shenmai Injection combined with Arterial Infusion Chemotherapy can enhance the efficacy and relieve side effects of chemotherapy, improve the quality of life of Elderly Patients with advanced Non-small Cell Lung Cancer.%目的 观察参麦注射液联合动脉灌注化疗对老年非小细胞肺癌患者生活质量的影响.方法 2010年11月至2011年10月,将80例老年非小细胞肺癌患者随机分成治疗组40例与对照组40例.治疗组采用动脉灌注化疗联合参麦注射液,对照组采用单纯动脉灌注化疗,每4周治疗1次,2次治疗后评价近期疗效、化疗毒副反应发生率及患者生活质量.结果 治疗组与对照组总有效率分别为62.5％、40.0％,疾病控制率(DCR)分别为87.5％、67.5％;治疗组KPS评分改善明显高于对照组,两组比较差异有统计学意义(P＜0.05);化疗相关毒副反应发生率治疗组明显低于对照组,两组比较差异有统计学意义(P＜0.05).结论 参麦注射液联合动脉灌注化疗治疗老年非小细胞肺癌,可提高化疗疗效、减轻药物的毒副反应、改善患者生活质量.