目的：观察老年女性压力性尿失禁（ SUI ）患者生殖相关激素与体重指数的改变，分析相关性并探讨可能机制。方法79例SUI患者及18例非SUI患者纳入研究。根据尿失禁程度分为1级（ n＝27）、2级（ n＝34）、3级（n＝18）。记录所有患者的体重指数（BMI）并检测生殖相关激素水平（雌二醇、孕酮、睾酮、卵泡刺激素、黄体生成素），分析两者的相关性。结果3级SUI患者较1、2级患者体重指数明显增高（P＜0．05），而血清雌二醇（E2）反而降低（P＜0．05），其余生殖相关激素无明显改变（P＞0．05）。相关性分析提示：所有SUI患者体重指数与E2呈负相关（r＝－0．617，P＜0．05）。亚组分析，两者在SUI1、2、3级的相关值分别为－0．578，－0．624，－0．648（P＜0．05）。结论体重指数越高，SUI越严重，而E2越低，其余生殖相关激素变化不大；BMI 与E2呈显著负相关；两者相互作用又共同加重SUI。%Objective To observe the changes of reproductive hormones levels and body mass index ( BMI) in older women with stress urinary incontinence ( SUI) ,analyse the correlation and explore the possible mechanism .Methods 79 SUI patients and 18 non-SUI patients were enrolled in this study .According to the se-verity of disease ,the SUI patients were divided into three groups :grade 1group ( n=27 ) ,grade 2 group ( n =34),grade 3 group (n=18).The BMI was recorded and the serum reproductive hormones levels including es-tradiol,progesterone ,testosterone ,follicle stimulating and luteinizing hormone were measured .The correlation of both indics was analyzed .Results Compared to the grade 1 and 2 SUI patients,grade 3 SUI patients showed higher BMI ( P<0 .05 ) and lower serum estradiol levels ( P<0 .05 ) .No changes of the rest hormone levels were found in each group (P>0.05).The BMI was associated with the levels of estradiol and showed negative correlation (r=-0.617,P<0.05).Subgroup analysis suggested that the correlation value in each group was-0.578,-0.624,-0.648,respectively (P<0.05).Conclusio n The BMI is higher,the SUI is more serious, and the estradiol levels are lower .The remaining reproductive hormones changed little .BMI was negatively cor-related with estradiol ,and both of them aggravated the stress urinary incontinence together .
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