Prospective Evaluation of Hormone Replacement Therapy, Body Mass Index, Estrogen Metabolism and Breast Cancer Risk

摘要

The objective of this project is to prospectively evaluate the extent to which BMI and estrogen metabolism are related to breast cancer associated with HRT use. We will specifically test the following hypotheses: Among postmenopausal women using HRT: (a). the risk of breast cancer is higher for women with higher serum 16-OH levels (b). lower BMI is associated with higher serum 16-OH levels (c). therefore: the risk of breast cancer increases with decreasing BMI We will also test the relationship between serum 2-OH levels, the2:16-OH ratio, BMI and breast cancer risk. This will be done using a nested case/control study within the observational arm of the Womens Health initiative.