芳香族羧酸银（I）配合物的合成及其抑制脲酶的研究

摘要

Four new silver(I) complexes with aromatic carboxylates,[Ag2(L1)2(A1)2]2·H2O(1),[Ag2(L2)2(A2)3]· H2O(2),[Ag(A3)2]2(L3)·10H2O(3) and [Ag2(A4)2](L4)·4H2O(4)(HL1=3-pyridinemethanoic acid;HL2=3,5-dinitrobenzoic acid;H2L3=p-phthalic acid;H2L4=4,4’-biphthalic acid;A1=2-aminopyridine;A2=2-aminopyrimidine;A3=4-aminopyridine;A4=1,6-hexyldiamine),have been synthesized and structurally characterized.Inhibition of jack bean urease by these Ag(I) complexes have been investigated.The Ag(I) complexes (1) (4) possess urease inhibitory activities and complex 3 has the best activity to inhibit urease.It was found that the urease inhibition activity of Ag(I) complexes would decrease with their structural polymerization degree increasing.%合成并表征了4种羧酸银(I)配合物：[Ag2(L1)2(A1)2]2·H2O（1），[Ag2(L2)2(A2)3]·H2O（2），[Ag(A3)2]2(L3)·10H2O（3）和[Ag2(A4)2](L4)·4H2O（4）（HL1=3-吡啶甲酸；HL2=3，5-二硝基苯甲酸；H2L3=对苯二甲酸；H2L4=4，4’-联苯二甲酸；A1=2-氨基吡啶；A2=2-氨基嘧啶；A3=4-氨基吡啶；A4=1，6-己二胺）。测定了这4种羧酸银(I)配合物抑制脲酶（urease）的效果。实验结果表明4种羧酸银(I)配合物均具有抑制脲酶的生物活性，其中配合物3的抑制活性最强。研究发现它们抑制脲酶的能力随着羧酸银(I)配合物分子聚合程度的增大而减弱。