In an open multicenter prospective study, the effects of short-term (4weeks, n= 101) and long-term (6 months, n = 38) terazosin treatment on blood pressure, serum lipids and safety in the patients with mild to moderate essential hypertension were observed. Mean systolic and diastolic blood pressure in sitting position were significantly reduced by 16. 4 % and 14. 0 % respectively (P<0.01 ) after 4 weeks of terazosin therapy, with the total efficacy rate being 87.1 %.During a 6 month therapy, antihypertensive effect of terazosin could be main-tained- Total cholesterol (TC) and low density lipoprotein (LDL ) cholesterol in serum were significantly decreased P < 0. 05-0.01) in patients with hyperc-holesterolemia (TC≥6 mmol/ml)after 4 week terazosin treatment; the levels of TC, LDL and triglyceride were significantly improved in hypertensive patients af-ter 3-6 month terazosin treatment. The improvement of lipid metabolism was re-lated to the dosage of terazosin but not to antihypertensive effects of terazosin.The results suggested that terazosin is effective in decreasing blood pressure and improving lipid metabolism. It may serve as a good antihypertensive agent for hy-pertensive patients with hypercholesterolemia.
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