Preparation of Arsenic Trioxide Albumin Microspheres and its Release Characteristics in Vitro

摘要

Arsenic trioxide albumin microspheres （As2O3-BSA-NS） were prepared by using methods of chemical cross-linking. The desirability function （DF）, calculated according to the size （0.05）. The release experiment in vitro showed that As2O3 in As2O3-BSA-NS was released more slower than pure As2O3. It was concluded that regular As2O3-BSA-NS may be prepared by the methods of chemical cross-linking, which was optimized by orthogonal experimental analysis of different factors, and the microspheres can release As2O3 slowly.