咪唑-4,5-二羧酸衍生物的合成

摘要

研究了以1H-咪唑-4,5-二羧酸（1）为原料合成1H-咪唑-4,5-二甲酸乙酯（2）和1H-咪唑-4,5-二酰胺（3）的方法和条件,初步考察了催化剂、反应时间、物料比等因素对反应和产率的影响.产品结构经1HNMR、IR和MS表征.%The synthetic methods and conditions of diethyl 1H-imidazole-4,5-dicarboxylate（2） and 1H-imidazole-4,5-dicarboxamide（3） were studied using 1H-imidazole-4,5-dicarboxylic acid（1） as a starting material.Influence of catalysts,reaction time and amounts of reactants on yields of products was preliminarily investigated.Compounds 2 and 3 were characterised by 1H NMR、IR and MS.