女性生殖道支原体感染情况及临床耐药分析

摘要

目的：分析女性生殖道支原体感染情况及耐药趋势，为临床合理规范使用抗生素提供帮助。方法对我院妇科门诊311例患者的生殖道分泌物标本进行支原体培养，并同时进行10种抗生素的药敏试验。结果女性生殖道分泌物支原体感染阳性190例（61．1％），其中解脲支原体感染175例（56．3％），解脲和人型混合感染11例（3.5％），人型支原体感染4例（1．3％）；解脲支原体感染的药物敏感率以交沙霉素和克拉霉素最高（100％），其次是美满霉素和强力霉素（98．9％），再次是四环素（85．2％），敏感率低于50％的药物分别是左氧氟沙星、司巴沙星、阿奇霉素和氧氟沙星。结论对妇科就诊患者应根据临床症状尽早进行支原体培养和药敏试验，以便尽早快速确定病因，为合理用药和准确确定诊疗方案提供依据。%Objective To analyze female genital tract mycoplasma infection situation and drug resistance tendency ,advo-cate clinical reasonable use of antibiotics , and provide a solid basis for correct clinical diagnosis and treatment .Methods Genital tract secretion samples of 311 cases of gynaecology outpatients of Huaiyuan County were collected , mycoplasma was cultured and antibiotics susceptibility test against 10 antibiotics was conducted .Results Positive mycoplasma infection of fe-male genital tract secretion occurred in 190 cases (61.1%), including 175 cases of ureaplasma mycoplasma infection (56. 3%),11 cases of mixed ureaplasma urealyticum (UU) and mycoplasma hominis (MH) infection (3.5%) and 4 cases of MH infection (1.3%).Josamycin and clarithromycin demonstrated the highest drug susceptibility rate (100%) for UU infection, followed by minocin and doxycycline (98.9%),and tetracycline (85.2%).Among the drugs with susceptibility rate lower than 50%were levofloxacin,sparfloxacin,azithromycin and ofloxacin.Conclusion Mycoplasma culture and antibiotics sus-ceptibility test should be conducted as early as possible on gynaecology patients based on clinical symptoms in order to quickly identify the cause and provide basis for rational drug use and accurate diagnosis and treatment .