Objective To study the clinical manifestation, pathological features and their correlation in children patients with Henoch-Sch?nlein purpura nephritis. Methods The clinicopathological data of 87 biopsy-proven cases of HSPN from Jan. 2008 to Dec. 2013 were retrospectively analyzed. Results The average age of the patients was 8.63 ± 2.71 years old. Clinically, hematuria and proteinuria was the most common clinical type (43,49.4%), followed by nephrit-ic syndrome(22,25.3%). The majority of pathological changes of HSPN were gradeⅢwith 41 cases(47.1%) andⅡwith 39 cases(44.8%). The IgA fluorescence intensity ofwas the most common seen in HSPN, accounting for 47.1%andwas the next in order, accounting for 34.5%.Immunopathological results showed that merely staining of IgA in mesangial area was in 12 patients, accounting for 13.8%. Staining of IgA combined with IgG was in 5.7%of 87 patients. Staining of IgA combined with IgM was in 44.8%. 70 patients had C3 deposit, accounting for 80.5%. Conclusion HSPN has high morbidity rate in children and has diverse clinical manifestation and pathological changes. Early renal biopsy should be performed in the patients who are doubted to be HSPN to clarify the diagnosis and guide treatment.%目的 探讨儿童过敏性紫癜性肾炎患者的临床表现、病理特点及其相关性.方法 回顾性总结分析经临床及肾活检确诊为过敏性紫癜性肾炎的87例患儿的临床表现及病理特点.结果 紫癜性肾炎87例,平均年龄为8.63岁.其临床表现多样化,血尿和蛋白尿43例,占49.4%;其次为肾病综合征型22例,占25.3%;肾脏病理分级以Ⅲ和Ⅱ级最为常见,分别为41例(47.1%)、39例(44.8%).免疫病理方面IgA者者41例,占47.1%,者30例,占34.5%.单纯IgA阳性者12例,占13.8%;合并IgG沉积者5例,占5.7%;合并IgM的沉积者39例,占44.8%;合并补体C3沉积者70例,占80.5%.结论 紫癜性肾炎在儿童发病率高,危害性较大.其临床表现及病理改变多种多样,临床疑似紫癜性肾炎患者建议肾活检以明确诊断.
展开▼
