氧化型低密度脂蛋白抗体与成人急性淋巴细胞性白血病相关性研究

摘要

目的 探讨氧化型低密度脂蛋白(oxidized low density lipoprotein,oxLDL)抗体与成人急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)发病的相关性.方法 测定57例ALL患者及50例健康对照者血清总蛋白、白蛋白、胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、IgG、IgA、IgM 、oxLDL、oxLDL-IgG抗体及oxLDLIgM抗体.结果 ALL组血清总蛋白、白蛋白、胆固醇、低密度脂蛋白及oxLDL-IgG抗体水平低于对照组,oxLDL、oxLDL-IgM 抗体高于对照组.ALL患者血清oxLDL-IgG与总蛋白、胆固醇及低密度脂蛋白呈直线正相关,与oxLDL呈直线负相关;oxLDL-IgM 水平与总蛋白、胆固醇及低密度脂蛋白呈直线负相关.oxLDL-IgG升高是成人ALL发病的保护因素,oxLDL-IgM 升高是成人ALL发病的危险因素.结论 成人ALL患者可出现脂质代谢障碍及脂质过氧化作用增强,ALL的发生与oxLDL-IgG降低及oxLDL-IgM 升高有关.%Objective To investigate the correlation between oxidized low density lipoprotein (oxLDL) antibody and adult acute lymphoblastic leukemia (ALL). Methods A total of 57 patients with adult ALL and 50 healthy controls were enrolled. Serum total protein, albumin, cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, IgG, IgA, IgM, oxLDL, oxLDL-IgG and oxLDL-IgM were measured at the time of diagnosis. Results Serum total protein, albumin, cholesterol, LDL and oxLDL-IgG were lower and oxLDL, oxLDL-IgM were higher in ALL patients compared to controls. Serum oxLDL-IgG in ALL patients was positively correlated with total protein, cholesterol and LDL, whereas negatively correlated with oxLDL. Total protein, cholesterol and LDL were negatively correlated with oxLDL-IgM. According to binary logistic regression analyis, elevation of oxLDL-IgG was shown to be a protective factor and elevation of oxLDL-IgM to be a risk factor for the onset of adult ALL. Conclusion Dysregulated lipid metabolism and increased lipid peroxide levels could be observed in adult ALL patients and the occurrence of ALL was probably related to the decrease of oxLDLIgG and elevation of oxLDL-IgM.