血脂联合子宫动脉血流检测对子痫前期发病的预测价值

摘要

Objective To investigate the effect of lipid combined with uterine artery blood flow detection in diagnosis of preeclampsia.Methods Retrospective analysis was made on 200 preeclampsia women and 600 normal pregnant women who took prenatal tests in the Fourth Hospital of Hebei Medical University.The lipid levels during the first,second and third trimester were compared between normal and preeclampsia women.A total of 588 pregnant women were randomly selected,all women were detected the lipid level during first trimester and uterine artery blood flow during second trimester.The triglyceride level and uterine artery blood flow were all normal in group A.The triglyceride level was high but uterine artery blood flow was normal in group B.The uterine artery blood flow was high but the triglyceride level was normal in group C. The triglyceride level and uterine artery blood flow were all high in group D.The incidence of preeclampsia for the four groups were compared.Results For preeclampsia women,triglyceride during first trimester was significantly higher than normal pregnant women (P <0.05);During second and third trimester,triglyceride,cholesterol and low density lipoprotein were much higher (P <0.05).The incidence of preeclampsia for group D was significantly higher than other three groups (P < 0.05 ).Conclusion Preeclampsia women had metabolic abnormalities of lipid, especially triglyceride level was high from first trimester and continued high state.Lipid combined with uterine artery blood flow detection would have higher predictive value in diagnosis of preeclampsia.%目的：探讨血脂联合子宫动脉血流检测对子痫前期诊断的预测价值。方法回顾性分析在河北医科大学第四医院规律进行产前检查并分娩的子痫前期孕妇200例和健康孕妇600例资料，比较健康组孕妇与子痫前期组孕妇在孕早、中、晚期的血脂水平；随机选取588例在河北医科大学第四医院定期行产前检查并住院分娩的孕妇，对所有孕妇于孕早期进行血脂检测并于孕中期进行子宫动脉血流检测，将三酰甘油水平正常及子宫动脉血流正常的分为 A 组，孕早期三酰甘油水平升高及孕中期子宫动脉血流均正常的孕妇分为 B 组，将孕早期三酰甘油水平正常及孕中期子宫动脉血流增高的孕妇分为 C 组，三酰甘油及子宫动脉血流同时增高的孕妇分为 D 组，比较4组孕妇子痫前期发病率。结果子痫前期组孕妇孕早期三酰甘油明显高于健康组，差异有统计学意义（P ＜0．05），孕中期、晚期子痫前期组三酰甘油、胆固醇、低密度脂蛋白水平均明显高于健康组（P ＜0．05）；D 组子痫前期发病率明显高于其他3组（P ＜0．05）。结论子痫前期患者存在血脂代谢异常，尤其是三酰甘油水平于孕早期即明显升高并持续高水平状态；血脂联合子宫动脉血流检测对子痫前期发病有较高的预测价值。