半枝莲多糖对小鼠S180肉瘤抑制作用的研究

摘要

homoharringtonine; MTT; anticancer ; HepG2 cellsThis paper studied on the antitumor effect of Scutellaria barbata D. Don polyaccha-rides( SBP) on mice bearing S180 tumor. The effect of SBP on tumor growth and IL -2 INF -content were detected by ELISA detection method. The result showed that SBP could inhibit the growth of S180 and the effect of middle dose group was the best. Meanwhile, SBP could improve IL -2 and INF - a activity. This indicated that SBP could inhibit tumor S180 growth.%探讨半枝莲多糖对体内S180肉瘤肿瘤抑制作用及相关机制.采用动物移植性肿瘤实验观察半枝莲多糖对小鼠体内肿瘤细胞生长的影响,ELISA法检测对荷瘤小鼠外周血血清中白细胞介素-2和干扰素-α质量浓度的影响.结果显示,半枝莲多糖对S180肉瘤生长的抑制率以中剂量为佳;各剂量组均对脾脏指数有显著性差异,能够提高S180荷瘤小鼠外周血血清中白细胞介素-2及干扰素-α的质量浓度,但中剂量最为显著,表明半枝莲多糖在小鼠体内具有抑制S180肉瘤的作用.