结肠靶向滴丸克癌素包衣工艺及释放性能研究

摘要

To establish the coating technology of anti-cancer medicine with colon-targeting drug delivery system, the optimum coating prescription and coating methods of the prepara-tion were screened and ensured.According to the pH sensitive-time dual controlled release mechanism, this experiment will use ethyl cellulose aqueous dispersion ( Surlease) and the mixture of HPMC for sustained release layer and enteric acrylic resin type EudragitFS30 D for enteric layer.A new kind of pH-time dependent colon-targeting dropping pills drug deliv-ery system was prepared.The results showed that the ratio of the sustained release layer to the HPMC was 15:6, weight gain rate of slow release layer polymer was 4%, and weight gain rate of enteric layer FS30 D was 20%.The colon coating dropping pills prepared by this coating prescription and methods have a bright and beautiful appearance, a uniform and com-plete membrane and a stable release property.%建立结肠靶向给药系统克癌素滴丸的包衣工艺,筛选确定了该制剂最佳的包衣处方及包衣方法.根据pH敏感-时间控释双重机理,本实验将乙基纤维素水分散体( Surlease )和HPMC的混合液为缓释层,肠溶型丙烯酸树脂EudragitFS30D为肠溶层,制备了一种新型的pH-时间依赖型结肠定位滴丸给药系统.结果表明,缓释层Surelease与HPMC比例为15:6,缓释层聚合物增重百分数为4%,肠溶层FS30D增重百分数为20%.该包衣处方和方法制备的结肠包衣滴丸外观光洁美观,衣膜均匀完整,释放性能稳定.